Kenya has made significant progress in HIV prevention especially among children. However the reduction of new HIV infections among adults has been relatively slow. This HIV Prevention Road Map therefore draws from lessons learned on strategies, interventions and scientific development in HIV prevention globally. It provides guidance on how the country can accelerate and achieve a drastic reduction in new HIV infections in a manner which is evidence-informed, rights-based and gender sensitive. The process of developing this Road Map included review of globally available and accepted evidence of what works in HIV prevention, stakeholders’ consultation and policy review processes. This document provides targets and milestones that set Kenya on a clear path towards the goal of Zero new HIV infections.