Male Circumcision Significantly Reduces Prevalence and Load of Genital Anaerobic Bacteria

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Editor Score:
90
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Quality:
90
editor score
Usability:
90
editor score
Reliability:
90
Asset Type
License
Free
Expiration
Tuesday, February 24, 2026
Geography
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North America Central America South America Oceania Scandinavia Europe Africa Middle East Asia
Publication year
2013
Industry
Life science/Healthcare

Understanding the mechanisms that underlie the benefits of male circumcision could help to identify new intervention strategies for decreasing HIV transmission, applicable to populations with high HIV prevalence where male circumcision is culturally less acceptable. Male circumcision reduces female-to-male HIV transmission. Specifically, the prevalence and absolute abundance of 12 anaerobic bacterial taxa decreased significantly in the circumcised men. Hypothesized mechanisms for this protective effect include decreased HIV target cell recruitment and activation due to changes in the penis microbiome. IMPORTANCE The bacterial changes identified in this study may play an important role in the HIV risk reduction conferred by male circumcision.

Yegii expert:
Author:
Liu Et al
Publisher:
The American Society for Microbiology
Time horizon:
2-5 Years
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